| Biochemistry |
BCHM 802 - Endocrinology
Credits:
4.00
Biochemical and molecular structure and function of
vertebrate endocrine systems. Influence of endocrine
systems on the physiology of vertebrates, with special
reference to mammals. Current investigations of the
endocrine systems as a regulator and integrator of body
functions including such systems as growth, reproduction,
metabolism, differentiation, and behavior. Prereq: general
biochemistry or principles of biochemistry;/ or permission.
(Also offered as ANSC 802.) Special fee.
BCHM 811 - Genomics and Bioinformatics
Credits:
4.00
The methods, applications, and implications of genomics--the
analysis of whole genomes. Microbial, plant and animal
genomics are addressed, as well as medical, ethical and
legal implications. The lab provides exposure and experience
of a range of bioinformatics approaches--the computer
applications used in genome analysis. Prereq: Principles of
Genetics. (Also offered as GEN 811 and MICR 811.) Lab.
BCHM 850 - Physical Biochemistry
Credits:
3.00
Structure, interactions, and physical-chemical properties of
biomolecules. Thermodynamic, kinetic, and spectroscopic
methods for the study of proteins and nucleic acids. Prereq:
2 semesters organic chemistry, 1 semester of calculus;/ or
permission.
BCHM 851 - Principles of Biochemistry I
Credits:
4.00
In-depth survey of biochemistry: macromolecule structure;
structure and function of proteins, nucleic acids,
carbohydrates,and lipids. Prereq: organic chemistry, general
biochemistry or permission.
BCHM 852 - Principles of Biochemistry II
Credits:
4.00
Continuation of in-depth survey of biochemistry: metabolism
of amino acids, nucleotides, carbohydrates and lipids;
macromolecules synthesis and regulation; molecular biology
of the eukaryotic cell. Prereq: BCHM 851 or permission.
BCHM 854 - Laboratory in Biochemistry and Molecular Biology of Nucleic Acids
Credits:
5.00
Application of modern techniques to the analysis of
biomolecules, with an emphasis on nucleic acids; includes
DNA isolation and analysis, cloning and sequencing and
analysis of gene products. No credit if credit has been
received for microbial genetics. Prereq: general
biochemistry, principles of biochemistry or permission.
(Also offered as GEN 854 and PBIO 854.) Special fee. (Not
offered every year.)
BCHM 855 - Laboratory in Biochemistry and Molecular Biology
Credits:
5.00
Application of modern techniques to the characterization
and purification of biomolecules, with an emphasis on
proteins and nucleic acids; analysis of enzyme kinetics; and
basic techniques used in molecular biology. Prereq:
BCHM 851-852;/ or permission. BCHM 852 may be taken
concurrently with BCHM 855. Special fee.
Co-requisites:
BCHM 863 - Biochemistry of Cancer
Credits:
3.00
Molecular mechanisms of viral and chemical carcinogenesis;
role of ocogenes in normal cell growth, development, and
differentiation. Biochemical basis of cancer chemotherapy.
Critical reviews of research papers and an advanced research
paper required. Prereq: general biochemistry or BCHM 851 or
permission. Credit/Fail.
BCHM 866 - Environmental Genomics
Credits:
4.00
The field of environmental genomics uses existing and
developing high throughput genomic-scale technologies to
investigate ecological and evolutionary theory, and so
provides a more complete understanding of how organisms
respond to environmental change at the molecular genetic
level. Course covers an array of systems involved in this
emerging field, with the central aim of understanding the
effects of environmental change on genome structure, gene
expression, and adaptive evolutionary change. Information is
derived from the primary literature in the field and covers
practical and technical concepts as well as the underlying
theoretical basis for the major research themes. Prereq:
principles of genetics;/ or permission. (Also offered as GEN
866.)
BCHM 871 - Molecular Genetics
Credits:
4.00
Structure, organization, replication, dynamics, and
expression of genetic information in eukaryotes. Focus on
molecular genetic mechanisms of gene expression and its
control; molecular genetics methods; molecular genetic
control of cell division and differentiation during
development. Prereq: a general biochemistry or principles of
biochemistry course; a course in principles of genetics;/ or
permission. (Also offered as GEN 871.)
BCHM 882 - Developmental Genetics
Credits:
3.00
The molecular genetic basis of metazoan development. Course
focuses on how genes direct the process of development and
how this problem is analyzed in model organisms using
molecular genetic approaches. Topics include: control of
cell division, maternal factors, cell-cell interactions,
differential gene expression. Prereq: principles of
genetics. (Also offered as GEN 882.)
BCHM 890 - Current Topics in Biomedicine
Credits:
4.00
The dramatic advances in molecular biology and biochemistry
during the last two decades have led to explosive growth in
the accumulation of biomedical knowledge. To "discover" the
literature is an essential element of training in any
molecular discipline in biology. The first phase of the
course will cover the use of literature search tools, and
how to read scientific papers, write a review and make
presentations effectively. The bulk of the time will be
spent on current topics in biomedicine selected by the
class. With guidance from the instructor, the class will
derive reading lists, discuss the literature, and then write
short essays on each topic. Participants will also prepare a
"term" project for audiovisual presentation to the class in
the final two weeks. Prereq: BIOL 605 or instructor
permission.
BCHM 894 - Protein Structure and Function
Credits:
4.00
Analysis of how the three-dimensional architecture of
soluble and membrane proteins contributes to their
biochemical function. Topics include methods for determining
the structure of proteins, protein folding, protein
targeting, and mechanisms of enzyme catalysis. Computer
resources will be used for protein modeling and structural
prediction. Prereq: general biochemistry or principles of
biochemistry.
BCHM 895 - Investigations
Credits:
1.00 to 4.00
Independent study in various areas including but not limited
to: genetics, signal transduction, gene regulations,
molecular evolution, biochemistry of cancer, biophysics of
macromolecules, endocrinology, and glycobiology. May include
readings, laboratory work, organized seminars and
conferences. Prereq:permission. Not more than 4 total credit
hours can be applied to BCHM or major electives.
BCHM 899 - Master's Thesis
Credits:
1.00 to 10.00
Cr/F.
BCHM 902 - Endocrine Disruptors/Neuroendocrinology
Credits:
3.00
Biochemical and molecular mechanisms of neurohormones;
endocrine disruptors, mechanisms of achons of chemicals
mimicking or interfering with the action of hormones;
potential health effects of endocrine disrupting chemicals;
developmental neuroendocrinology; gene regulator by
hormones.
BCHM 942 - Biochemical Regulatory Mechanisms
Credits:
3.00
Transcriptional control and post-transcriptional
processing of mRNA; regulation and formation of
chromation structure; mRNA transport; degradation of
mRNA nonsense mediated decay; integration of decay,
decapping, and translational control.
Prereq: BCHM 852 or permission. (Also offered as
GEN 942.)
BCHM 950 - Macromolecular Interactions
Credits:
3.00
Interactions between macromolecules are central to all
biological processes. Focuses on the structures and
energetics that underlie these processes. Topics include
self-associations, hereto assembly, cooperativity, ligand
linkage and methods for their analysis. Prereq: physical
chemistry I, II or BCHM 850. May be repeated.
(Also listed as MS 910.)
BCHM 960 - Advanced Topics in Signal Transduction
Credits:
3.00
Examination of current topics in signal transduction
mechanisms. Pathways involving receptor activation,
G-protein activation, regulation of effector enzymes, and
changes in second messengers covered, along with mechanisms
for short- and long-term desensitization of cellular
responses.
BCHM #993 - Advanced Topics in Enzyme Regulatory Mechanisms
Credits:
3.00
Selected topics of current research in the molecular basis
of enzyme regulation. Emphasis on biochemical and molecular
biological approaches to determining the mechanisms by
which key regulatory enzymes are controlled. Prereq:
permission.
BCHM 997 - Seminar
Credits:
1.00
Prereq: permission. Cr/F.
BCHM 998 - Seminar
Credits:
1.00
Prereq: permission. Cr/F.
BCHM 999 - Doctoral Research
Credits:
Cr/F.