| Genetics |
GEN 802 - Genetics Lab
Credits:
4.00
An experimental approach to understanding the fundamental
principles of heredity. The lecture covers theoretical
aspects of genetics hypothesis testing, data analysis, and
techniques of isozyme and DNA electrophoresis and polymerase
chain reaction (PCR). In lab, students conduct mating and
mutagenesis experiments with plants, animals, and yeast; do
human DNA fingerprinting; employ techniques of DNA
isolation, electrophoresis, PCR, cytogenetics, and
statistical analysis to generate and interpret genetic data.
Prereq: principles of genetics or equivalent. (Also offered
as BIOL 802.) Special fee. Lab.
GEN 804 - Genetics of Prokaryotic Microbes
Credits:
4.00
Expression and transfer of genetic elements (chromosomal and
nonchromosomal) in prokaryotic and eukaryotic
microorganisms; consideration of factors influencing public
health, industry, the environment, and society. Students
earning credit for PBIO 754/854; BCHM 854/854;
GEN 754/854 may not receive credit for MICR 704/804.
Prereq: general mircobiology; biochemistry (Also offered as
MICR 804.) Lab.
GEN 805 - Population Genetics
Credits:
4.00
An exploration of the forces affecting the frequency and
distribution of allelic variation in natural populations.
The relative role of mutation, selection, random drift, and
inbreeding in structuring genetic variation. Quantification
of the genetic structure of populations. Prereq: principles
of genetics; applied biostatistics I recommended. (Also
offered as ZOOL 805.) Special fee. (Not offered every year.)
GEN 806 - Human Genetics
Credits:
3.00
The genetic basis of human traits and diseases. New
understanding added by molecular genetic approaches. Human
genome project, gene therapy. Discussion of genetic
components of quantitative and behavioral traits and human
evolution. (Not offered every year.) (Also offered as
ANSC 806.)
GEN 811 - Genetics of Eukaryotic Microbes
Credits:
4.00
Expression and transfer of genetic material in eukaryotic
microbes including fungi, algae, protozoa, and
Caenorhabditis elegans. Laboratory experience in DNA
sequence entry and retrieval and analysis. Macintosh
workstations are used for assessing and retrieving data from
the National Laboratory of Medicine and other sources via
the Internet. Prereq: general microbiology; principles of
genetics. (Also offered as BCHM 811 and MICR 811.)
Lab.
GEN 815 - Molecular Evolution
Credits:
4.00
Rates and patterns of evolutionary change in biomolecules.
Forces affecting the size and structure of genomes.
Molecular mechanisms of organismal evolution. Emphasis on
integrating evidence from biochemistry, molceular genetics
and organismal studies. Methods for reconstructing phylogeny
from molecular sequences. Prereq: princinples of genetics.
Some knowledge of statistics and familiarity with personal
computers is recommended. (Also offered as ZOOL 815.)
Special fee. Lab. (Not offered every year.)
GEN #822 - Immunogenetics
Credits:
4.00
Cellular interactions and immune regulatory mechanisms.
Genetics of the major histocompatibility complex, antibody
diversity, and immune responses. (Also offered as ANSC 822.)
(Offered alternate years.)
GEN 823 - Quantitative Genetics
Credits:
4.00
Analysis of continuous variations in populations
simultaneously segregating at multiple loci. Genetic and
nongenetic factors and the complex interactions between
them. Models and methods of analysis for both theoretical
and practical applications. Prereq: principles of genetics;
applied biostatistics I, strongly suggested. (Also offered
as ZOOL 823.) Special fee. Lab. (Not offered every year.)
GEN 853 - Cytogenetics
Credits:
4.00
Chromosome structure, function, and evolution. Eukaryotic
genome organization. Theory of, and laboratory techniques
for, cytogenetic analysis in plants and animals. Prereq:
principles of genetics. (Also offered as PBIO 853.) Special
fee. Lab. (Not offered every year.)
GEN 854 - Laboratory in Biochemistry and Molecular Biology of Nucleic Acids
Credits:
5.00
Application of modern techniques to the analysis of
biomolecules, with an emphasis on nucleic acids; includes
DNA isolation and analysis, cloning, sequencing, and
analysis of gene products. No credit if credit has been
received for MICR 804. Prereq: BCHM 658/659; 751, or
permission. (Also offered as BCHM 854 and PBIO 854.) Special
fee. Not offered every year.
GEN 871 - Molecular Genetics
Credits:
4.00
Structure, organization, replication, dynamics, and
expression of genetic information in eukaryotes. Focus
on molecular genetic mechanisms of gene expression and its
control; molecular genetics methods; molecular genetic
control of cell division and differentiation during
development. Prereq: a general biochemistry or priciples of
biochemistry course; a course in principles of genetics;/or
permission. (Also offered as BCHM 871.)
GEN 874 - Plant Biotechnology and Genetic Engineering
Credits:
3.00
Plant transformation and regeneration, gene isolation and
identification, structure and regulation of plant genes,
current applications of plant genetic engineering,
environmental and social implications. Prereq: BIOL 604 or
permission. (Also offered as PBIO 874.)
GEN 875 - Plant Biotechnology and Genetic Engineering Lab
Credits:
2.00
Techniques for genetic transformation and selection of
plants, analysis of foreign gene expression, and plant cell
and tissue culture. Coreq: PBIO or GEN 874. (Also offered as
PBIO 875.) Special fee. (Not offered every year.)
Co-requisites:
GEN 874
GEN 882 - Developmental Genetics
Credits:
3.00
The molecular genetic basis of metzoan development. Focuses
on how genes direct the process of development and how this
problem is analyzed in model organisms using molecular
approaches. Topics include: control of cell division,
maternal factors, cell-cell interactions, and differential
gene expression. Prereq: principles of genetics; general
biochemistry; BCHM 851. (Also offered as BCHM 882.)
GEN 899 - Master's Thesis
Credits:
1.00 to 10.00
Credit/Fail.
GEN #904 - Advanced Microbial Genetics
Credits:
4.00
Advanced studies in expression, regulation, recombination,
and transmission of genetic information in prokaryotic
microorganisms. Prereq: GEN 804; permission. (Also offered
as MICR 904.) Special fee. Lab. (Not offered every year.)
GEN 942 - Biochmcl Regulatory Mechanisms
Credits:
3.00
Nonreplicative functions of DNA; transcription and
translational control of protein synthesis; quantitative
regulation of proteins; regulation of metabolism by
hormones, allosteric regulation and repression; regulatory
mechanisms operating during development and differentiation.
Prereq: BCHM 852 or permission. (Also offered as BCHM 942.)
GEN 991 - Advanced Topics in Molecular Genetics
Credits:
3.00
Selected topics of current research in molecular genetics
including gene structure and function, chromosome structure,
and gene expression. Emphasis on eukaryotic model organisms
such as worms, flies, zebra fish, and mice. Prereq:
permission. (Also offered as BCHM 991.) May be repeated
to a maximum of 6 credits.
GEN 992 - Advanced Topics in Molecular Biology
Credits:
3.00
Selected topics of current research on the molecular biology
of gene regulation, protein interactions, and the AIDS
virus. Emphasis on eukaryotic systems such as yeast and
mammals. Prereq: permission. (Also offered as BCHM 992.)
May be repeated to a maximum of 6 credits.
GEN 995 - Special Topics
Credits:
2.00 to 4.00
Intended for study in specialty areas not ordinarily
included in other courses. May involve formal classes,
discussions, or independent investigations. Prereq:
permission.
GEN 996 - Special Topics in Genetics
Credits:
2.00 to 4.00
See description for GEN 995.
GEN 998 - Genetics Seminar
Credits:
1.00
Presentation and discussion of selected genetic topics.
May be repeated. Credit/Fail.
GEN 999 - Doctoral Research
Credits: