| Biochemistry |
BCHM 802 - Endocrinology
Credits:
4.00
Biochemical and molecular structure and function of
vertebrate endocrine systems. Influence of endocrine
systems on the physiology of vertebrates, with special
reference to mammals. Current investigations of the
endocrine systems as a regulator and integrator of body
functions including such systems as growth, reproduction,
metabolism, differentiation, and behavior. Prereq: general
biochemistry or principles of biochemistry;/ or permission.
(Also offered as ANSC 802.) Special fee.
BCHM 811 - Genetics of Eukaryotic Microbes
Credits:
4.00
Expression and transfer of genetic material in eukaryotic
microbes including fungi, algae, protozoa, and
Caenorhabditis elegans. Laboratory experience in DNA
sequence entry retrieval and analysis. Macintosh
workstations are used for accessing and retrieving data from
the National Laboratory of Medicine and other sources via
the Internet. Prereq: general microbiology; principles of
genetics. (Also offered as GEN 811 and MICR 811.) Lab.
BCHM 850 - Physical Biochemistry
Credits:
3.00
Structure, interactions, and physical-chemical properties of
biomolecules. Thermodynamic, kinetic, and spectroscopic
methods for the study of proteins and nucleic acids. Prereq:
BCHM 851 or permission.
BCHM 851 - Principles of Biochemistry
Credits:
4.00
In-depth survey of biochemistry; macromolecule structure;
metabolism of proteins, nucleic acids, carbohydrates, and
lipids; molecular biology of DNA, RNA, and protein synthesis
and regulation. Prereq: organic chemistry or permission.
BCHM 852 - Principles of Biochemistry
Credits:
4.00
See description for BCHM 851.
BCHM 854 - Laboratory in Biochemistry and Molecular Biology of Nucleic Acids
Credits:
5.00
Application of modern techniques to the analysis of
biomolecules, with an emphasis on nucleic acids; includes
DNA isolation and analysis, cloning and sequencing and
analysis of gene products. No credit if credit has been
received for microbial genetics. Prereq: general
biochemistry, principles of biochemistry or permission.
(Also offered as GEN 854 and PBIO 854.) Special fee. (Not
offered every year.)
BCHM 855 - Laboratory in Biochemistry and Molecular Biology
Credits:
5.00
Application of modern techniques to the characterization
and purification of biomolecules, with an emphasis on
proteins and nucleic acids; analysis of enzyme kinetics; and
basic techniques used in molecular biology. Prereq:
BCHM 851-852;/ or permission. BCHM 852 may be taken
concurrently with BCHM 855. Special fee.
Co-requisites:
BCHM 852
BCHM #860 - Cellular Signaling Processes
Credits:
4.00
Biochemical mechanisms of signal transduction. Current
investigations of signaling pathways activated by hormones,
neurotransmitters, or sensory stimuli. Regulation of signal
transduction pathways in health and in disease, with special
emphasis on mammalian sensory systems such as vision,
olfaction, and gustation. Prereq: principles of biochemistry
or permission.
BCHM 863 - Biochemistry of Cancer
Credits:
3.00
Molecular mechanisms of viral and chemical carcinogenesis;
role of ocogenes in normal cell growth, development, and
differentiation. Biochemical basis of cancer chemotherapy.
Critical reviews of research papers and an advanced research
paper required. Prereq: general biochemistry or BCHM 851 or
permission. Credit/Fail.
BCHM 864 - Membrane Biochemistry
Credits:
3.00
Structure and biogenesis of membranes and membrane proteins,
transport across the membrane and bioenergetic membranes,
mechanisms of protein targeting, processing, and
trafficking. Prereq: general biochemistry; principles of
biochemistry;/ or permission.
BCHM #865 - Molecular Biology and Biochemistry of Plants
Credits:
3.00
Molecular mechanisms and regulation of plant metabolic
functions. Structure and function of cellular constituents
of plants; roles of secondary metabolites. Emphasis is on
developments in current literature. Complements PBIO
874/875. Prereq: general biochemistry or BCHM 851;
principles of genetics or permission. (Also offered as PBIO
865.)
BCHM 871 - Molecular Genetics
Credits:
4.00
Structure, organization, replication, dynamics, and
expression of genetic information in eukaryotes. Focus on
molecular genetic mechanisms of gene expression and its
control; molecular genetics methods; molecular genetic
control of cell division and differentiation during
development. Prereq: a general biochemistry or principles of
biochemistry course; a course in principles of genetics;/ or
permisison. (Also offered as GEN 871.)
BCHM 882 - Developmental Genetics
Credits:
3.00
The molecular genetic basis of metazoan development. Course
focuses on how genes direct the process of development and
how this problem is analyzed in model organisms using
molecular genetic approaches. Topics include: control of
cell division, maternal factors, cell-cell interactions,
differential gene expression. Prereq: principles of
genetics. (Also offered as GEN 882.)
BCHM 894 - Protein Structure and Function
Credits:
3.00
Analysis of how the three-dimensional architecture of
proteins and enzymes contributes to their biochemical
function. Topics include methods for determining the
structure of proteins, protein folding, intermolecular
interactions of proteins, mechanisms of enzyme catalysis,
enzyme kinetics, protein evolution and biosynthesis. Prereq:
general biochemistry or principles of biochemistry.
BCHM 895 - Investigations in Biochemistry and Molecular Biology
Credits:
1.00 to 4.00
Independent research experience in the following areas:
genetics, signal transduction, gene regulations, molecular
evolution, biochemistry of cancer, biophysics of
macromolecules, biochemical and molecular endocrinology,
plant signal transduction, and teaching experience. Prereq:
permission. Not more than 4 total credit hours can be
applied to BCHM or major electives.
BCHM 899 - Master's Thesis
Credits:
1.00 to 10.00
Credit/Fail.
BCHM 902 - Endocrine Disruptors/Neuroendocrinology
Credits:
3.00
Biochemical and molecular mechanisms of neurohormones;
endocrine disruptors, mechanisms of achons of chemicals
mimicking or interfering with the achon of hormones;
potential health effects of endocrine disrupting chemicals;
developmental neuroendocrinology; gene regulator by
hormones.
BCHM 942 - Biochemical Regulatory Mechanisms
Credits:
3.00
Nonreplicative functions of DNA; transcription and
translational control of protein synthesis; quantitative
regulation of proteins; regulation of metabolism by
hormones, allosteric regulation and repression; regulatory
mechanisms operating during development and differentiation.
Prereq: BCHM 852 or permission. (Also offered as GEN 942.)
BCHM 950 - Macromolecular Interactions
Credits:
3.00
Interactions between macromolecules are central to all
biological processes. Focuses on the structures and
energetics that underlie these processes. Topics include
self-associations, hereto assembly, cooperativity, ligand
linkage and methods for their analysis. Prereq: physical
chemistry I, II or BCHM 850. May be repeated.
BCHM 960 - Advanced Topics in Signal Transduction
Credits:
3.00
Examination of current topics in signal transduction
mechanisms, with emphasis on sensory transduction.
Pathways involving receptor activation, G-protein
activation, regulation of effector enzymes, and changes in
second messengers covered, along with mechanisms for
short- and long-term desensitization of cellular responses.
Prereq: BCHM 860 or permission.
BCHM 991 - Advanced Topics in Molecular Genetics
Credits:
3.00
Selected topics of current research in molecular genetics
including gene structure and function, chromosome structure,
and gene expression. Emphasis on eukaryotic model organisms
such as worms, flies, zebra fish and mice. Prereq:
permission. (Also offered as GEN 991.) May be repeated to a
maximum of 6 credits.
BCHM 992 - Advanced Topics in Molecular Biology
Credits:
3.00
Selected topics of current research on the molecular biology
of gene regulation, protein interaction, and the AIDS virus.
Emphasis on eukaryotic systems such as yeast and mammals.
Prereq: permission. (Also offered as GEN 992.) May be
repeated to a maximum of 6 credits.
BCHM 993 - Advanced Topics in Enzyme Regulatory Mechanisms
Credits:
3.00
Selected topics of current research in the molecular basis
of enzyme regulation. Emphasis on biochemical and molecular
biological approaches to determining the mechanisms by
which key regulatory enzymes are controlled. Prereq:
permission.
BCHM 997 - Biochemistry Seminar
Credits:
1.00
Prereq: permission. Credit/Fail.
BCHM 998 - Biochemistry Seminar
Credits:
1.00
Prereq: permission. Credit/Fail.
BCHM 999 - Doctoral Research
Credits: